| The Bank of New York (Nominees) Limited |
87,763,271 |
£62,311,922 |
| Harwood Capital LLP |
70,315,021 |
£49,923,665 |
| AstraZeneca PLC |
66,093,108 |
£46,926,107 |
| Nortrust Nominees Limited |
58,832,384 |
£41,770,993 |
| State Street Nominees Limited |
51,334,357 |
£36,447,394 |
| Imperial Innovations Businesses LLP |
47,355,417 |
£33,622,346 |
| Rathbones Investment Management Ltd |
41,753,708 |
£29,645,133 |
| Chase (GA Group) Nominees Limited |
36,606,654 |
£25,990,724 |
| Oryx International Growth Fund Limited |
30,000,000 |
£21,300,000 |
| PH Nominees Limited |
28,324,296 |
£20,110,250 |
| Chase Nominees Limited |
23,185,617 |
£16,461,788 |
| Charles Stanley Group Plc |
21,045,925 |
£14,942,607 |
| Raymond James Wealth Management Limited |
20,866,227 |
£14,815,021 |
| Lombard Odier Asset Management (Europe) Limited |
18,133,419 |
£12,874,728 |
| Neptune Investment Management Limited |
17,909,985 |
£12,716,089 |
| Invesco Limited |
15,660,000 |
£11,118,600 |
| Danske Bank A/S |
13,235,132 |
£9,396,944 |
| CIP Merchant Capital Limited |
12,800,000 |
£9,088,000 |
| Odey Asset Management LLP |
12,688,236 |
£9,008,648 |
| Lansdowne Partners International Limited |
7,893,712 |
£5,604,536 |