| The Bank of New York (Nominees) Limited |
87,763,271 |
£62,662,976 |
| Harwood Capital LLP |
70,315,021 |
£50,204,925 |
| AstraZeneca PLC |
66,093,108 |
£47,190,479 |
| Nortrust Nominees Limited |
58,832,384 |
£42,006,322 |
| State Street Nominees Limited |
51,334,357 |
£36,652,731 |
| Imperial Innovations Businesses LLP |
47,355,417 |
£33,811,768 |
| Rathbones Investment Management Ltd |
41,753,708 |
£29,812,148 |
| Chase (GA Group) Nominees Limited |
36,606,654 |
£26,137,151 |
| Oryx International Growth Fund Limited |
30,000,000 |
£21,420,000 |
| PH Nominees Limited |
28,324,296 |
£20,223,547 |
| Chase Nominees Limited |
23,185,617 |
£16,554,530 |
| Charles Stanley Group Plc |
21,045,925 |
£15,026,790 |
| Raymond James Wealth Management Limited |
20,866,227 |
£14,898,486 |
| Lombard Odier Asset Management (Europe) Limited |
18,133,419 |
£12,947,261 |
| Neptune Investment Management Limited |
17,909,985 |
£12,787,729 |
| Invesco Limited |
15,660,000 |
£11,181,240 |
| Danske Bank A/S |
13,235,132 |
£9,449,884 |
| CIP Merchant Capital Limited |
12,800,000 |
£9,139,200 |
| Odey Asset Management LLP |
12,688,236 |
£9,059,400 |
| Lansdowne Partners International Limited |
7,893,712 |
£5,636,110 |