| Redmile Group, LLC |
297,188,365 |
£29,124,460 |
| Vulpes Investment Management Pte Ltd |
143,537,037 |
£14,066,630 |
| VULPES LIFE SCIENCES FUND |
140,387,037 |
£13,757,930 |
| VULPES LIFE SCIENCES FUND |
117,729,029 |
£11,537,445 |
| Ferlim Nominees Limited |
50,632,079 |
£4,961,944 |
| Reyker Nominees Ltd |
48,464,691 |
£4,749,540 |
| Hargreaves Lansdown |
33,619,839 |
£3,294,744 |
| Share Nominees Ltd. |
29,887,768 |
£2,929,001 |
| The Bank of New York Nominees Limited |
21,287,775 |
£2,086,202 |
| Legal & General Group Plc |
18,167,000 |
£1,780,366 |
| Nortrust Nominees Limited |
18,167,000 |
£1,780,366 |
| City Financial Investment Company Limited |
16,287,775 |
£1,596,202 |
| Barclayshare Nominees Ltd |
15,650,629 |
£1,533,762 |
| Lynchwood Nominees Ltd. |
15,085,721 |
£1,478,401 |
| Rock Nominees Limited |
13,445,702 |
£1,317,679 |
| Hygea VCT |
13,149,730 |
£1,288,674 |
| Huntress Nominees (CI) Limited |
11,309,220 |
£1,108,304 |
| Layton Trustees & L.G. Durrant |
8,773,960 |
£859,848 |
| JG Helfenstein |
7,000,000 |
£686,000 |