| North London Ventures Limited |
243,461,685 |
£260,504,003 |
| The Wellcome Trust |
186,000,000 |
£199,020,000 |
| BlackRock, Inc. |
58,906,849 |
£63,030,328 |
| Smith and Williamson Holdings Limited |
32,849,272 |
£35,148,721 |
| Waverton Investment Management Limited |
31,640,760 |
£33,855,613 |
| Sarasin & Partners LLP |
30,934,159 |
£33,099,550 |
| Schroders plc |
30,404,532 |
£32,532,849 |
| Legal & General Group Plc (Group) |
26,834,153 |
£28,712,544 |
| J O Hambro Investment Management Limited |
23,218,940 |
£24,844,266 |
| RATHBONE BROTHERS PLC |
22,583,470 |
£24,164,313 |
| Cazenove Capital Management Limited |
20,177,500 |
£21,589,925 |
| Bestinvest (Brokers) Limited |
19,649,263 |
£21,024,711 |
| J.M. FINN & CO LTD |
19,181,655 |
£20,524,371 |
| Bestinvest (Brokers) Limited |
18,125,820 |
£19,394,627 |
| Royal Bank of Canada |
10,621,570 |
£11,365,080 |