| Vulpes Life Sciences Fund |
618,542,844 |
£1,042,245 |
| Pentwater Capital Management LP |
500,000,000 |
£842,500 |
| Unicorn Asset Management Limited |
278,464,859 |
£469,213 |
| Sankofa Strategic Equity Fund Limited |
211,855,049 |
£356,976 |
| Trafalgar Capital Management (HK) Limited |
130,316,163 |
£219,583 |
| Arbuthnot Latham (Nominees) Limited |
74,250,303 |
£125,112 |
| William Henry Salomon |
60,000,000 |
£101,100 |
| Odey Funds |
26,945,092 |
£45,402 |
| Lombard Odier Asset Management (Europe) Limited |
15,568,816 |
£26,234 |
| Dr Yavuz Ahiska |
10,577,600 |
£17,823 |
| Seneca Partners Limited |
9,978,822 |
£16,814 |
| Armistice Capital LLC |
7,791,803 |
£13,129 |
| Investec Wealth & Investment Limited |
7,319,886 |
£12,334 |
| The Chancellor, Masters and Scholars of the University of Oxford |
5,724,476 |
£9,646 |
| GL Healthcare Investment L.P. |
4,688,000 |
£7,899 |
| PHILIPPA MARGARET HOYER MILLAR |
4,473,140 |
£7,537 |
| The Goldman Sachs Group, Inc. |
4,404,088 |
£7,421 |