| Octopus Investments Limited |
1,600,000,000 |
£1,840,000 |
| Pentwater Capital Management LP |
1,200,000,000 |
£1,380,000 |
| Vulpes Life Sciences Fund |
618,542,844 |
£711,324 |
| Unicorn Asset Management Limited |
278,464,859 |
£320,235 |
| Sankofa Strategic Equity Fund Limited |
211,855,049 |
£243,633 |
| 6 OCEANS CAPITAL PARTNERS PTY LIMITED |
130,316,163 |
£149,864 |
| Arbuthnot Latham (Nominees) Limited |
74,250,303 |
£85,388 |
| William Henry Salomon |
60,000,000 |
£69,000 |
| Odey Funds |
26,945,092 |
£30,987 |
| Lombard Odier Asset Management (Europe) Limited |
15,568,816 |
£17,904 |
| Dr Yavuz Ahiska |
10,577,600 |
£12,164 |
| Seneca Partners Limited |
9,978,822 |
£11,476 |
| Armistice Capital LLC |
7,791,803 |
£8,961 |
| Investec Wealth & Investment Limited |
7,319,886 |
£8,418 |
| The Chancellor, Masters and Scholars of the University of Oxford |
5,724,476 |
£6,583 |
| GL Healthcare Investment L.P. |
4,688,000 |
£5,391 |
| PHILIPPA MARGARET HOYER MILLAR |
4,473,140 |
£5,144 |
| The Goldman Sachs Group, Inc. |
4,404,088 |
£5,065 |